Introduction : Herbal medicines have been used in the field of medical, nutraceuticals and cosmetics industry. Aegeline is an important phytoconstituents of Aegle marmelos traditionally used for the treatment of numerous disorders including liver disorders. Liver enzymes play an important role in indication of normal hepatocyte function, especially ALT and AST.

Methods : Various pharmacological activities of aegeline have been evaluated and presented in the various literatures. Present work summarizes important pharmacological activities of aegeline for the treatment of human liver disorders through peripheral lipid clearance and restoration of alanine transaminase (ALT), aspartate transaminase (AST), super oxide dismutase (SOD), catalase and glutathione peroxidase (Gpx) and Catalase enzymes. Docking analyses was also performed in this study to provide better support for their claimed pharmacological activities with reference to binding energies, distances and angles.

Results : Data analysis from different literature sources showed that aegeline had hepatoprotective potential. Aegeline has also significantly decreased the plasma triglyceride levels, total cholesterol, and free fatty acids accompanied with increase in HDL-C and HDL-C/TC ratio. Molecular docking studies strongly support the assumption of its anti-dyslipidemic and hepatoprotective activity through various docking analysis with various protein molecule against live enzymes ALT, AST, SOD and Catalase in terms of binding affinity and minimization of free energy with enzyme ligand complex.

Conclusions : Present work summarized the importance of aeglin in the regulation of triglyceride, cholesterol, free fatty acids level and restoration of various liver enzymes which will be beneficial for the treatment of liver disorders and associated secondary complications.