Detailed Abstract
[Liver Oral Presentation 1]
[LV OP 1-7] Clinical feature and prognosis of Multiple primary Malignancies in patients with HCC underwent surgical resection
Xu-Guang HU1, HeeJung WANG*2, Bowon KIM2, Sung-Yeon HONG2, Mina KIM2
1Department of hepatobiliary Surgery, JiangXi cancer Hospital, Nanchang, China, China
2Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery,, Ajou University School of Medicine, Suwon, Korea, Korea
Introduction : Multiple primary malignancies are defined as two or more different malignancies detected synchronously or metachronously in different organs of an individual patient. The aim of the present study was to investigate the clinicopathologic features for the HCC patients with multiple primary malignancies.
Methods : Between May 1997 and July 2016, 1043 HCC patients had been received radical surgical treatment in our institute. Among them 58 (5.6%) cases were diagnosed with extra-hepatic primary malignancies. The clinicopathologic features including Age, Sex, HBs Ag (positive), HCV Antibody (positive), AFP(more than 400ng/ml), tumor size (more than 5cm), multiple tumor number, microvascular invasion, Edmondson grade (grade 3 and 4), cirrhosis (fibrosis stage 4), AJCC staging for HCC (Stage 1). All the data were retrospectively analyzed form the database of our institute which were prospectively collected.
Results : The median follow up time is 53 months in the present study. Of the 58 (5.6%) multiple malignancies patients, 8 were diagnoses synchronously and 50 metachronously; 14 patients’ extra hepatic primary malignancies occurred prior to their HCC diagnoses, and 36 after their HCC diagnoses.The 5 years OS rate for multiple and single primary tumor were 77.8% and 66.9%, respectively (P=0.036). The multiple primary tumor patients have the following clinicopathologic features: older mean age, more patients with non-viral background liver, fewer patients with liver cirrhosis and more patients with AJCC stage I for HCC.
Conclusions : The patients with multiple primary tumors have a relatively good prognosis in our institute mostly due to the factors of non-viral background liver and early tumor stage.
Methods : Between May 1997 and July 2016, 1043 HCC patients had been received radical surgical treatment in our institute. Among them 58 (5.6%) cases were diagnosed with extra-hepatic primary malignancies. The clinicopathologic features including Age, Sex, HBs Ag (positive), HCV Antibody (positive), AFP(more than 400ng/ml), tumor size (more than 5cm), multiple tumor number, microvascular invasion, Edmondson grade (grade 3 and 4), cirrhosis (fibrosis stage 4), AJCC staging for HCC (Stage 1). All the data were retrospectively analyzed form the database of our institute which were prospectively collected.
Results : The median follow up time is 53 months in the present study. Of the 58 (5.6%) multiple malignancies patients, 8 were diagnoses synchronously and 50 metachronously; 14 patients’ extra hepatic primary malignancies occurred prior to their HCC diagnoses, and 36 after their HCC diagnoses.The 5 years OS rate for multiple and single primary tumor were 77.8% and 66.9%, respectively (P=0.036). The multiple primary tumor patients have the following clinicopathologic features: older mean age, more patients with non-viral background liver, fewer patients with liver cirrhosis and more patients with AJCC stage I for HCC.
Conclusions : The patients with multiple primary tumors have a relatively good prognosis in our institute mostly due to the factors of non-viral background liver and early tumor stage.
SESSION
Liver Oral Presentation 1
Room A 7/27/2020 12:22 PM - 12:30 PM