Introduction : Direct vascular invasion of intrahepatic cholangiocarcinoma (ICC) has bad prognosis. Results of liver resection with resection of visceral vessels in ICC are not well studied until now

Methods : A total of 84 patients underwent radical liver resection for ICC between 2004 and 2018. Perioperative characteristics, postoperative morbidity, mortality and survival were analyzed between patients with hepatectomy and major vascular resection (group 1, n=28) and patients with liver resection (group 2, n=56)

Results : We identified visceral vascular resection in patients with ICC as resection of inferior vena cava and/or portal vein with subsequent reconstruction. Gender (p=0,12), body mass index distribution (p=0,61), average duration of hospitalization (p=0,4) were comparable between groups. PTBD and PVE were performed in 14,3% and 12,5% (p=0,1) and 35,7% and 19,6% (p=0,81) of patients respectively. Resection type showed more equable distribution of extended hemihepatectomy between groups (42,9% vs 46,5%, p=0,32) with higher incidence of trisectenectomy in group 1 (53,5% vs 21,4%, p=0,002). Incidence of surgical site infections (17,85% vs 19,6%, p=0,84), posthepatectomy liver failure (25% vs 17,8%, p=0,44), reoperation (10,7% vs 8,9%, p=0,79), clinically relevant complications (25% vs 30,4%, p=0,26) were comparable between groups. 1-, 3‐year OS (61,2% vs 64,4%, p=0,04; 27.8% vs 34,1%, p=0,06) were comparable between groups.

Conclusions : Resection of ICC with visceral vascular resection is not associated with an increased perioperative risk and offers acceptable long-term survival.