Detailed Abstract
[E-poster]
[EP089] Comparisons of short-term and long-term outcomes between open and laparoscopic distal pancreatectomy in patients with pancreatic ductal adenocarcinoma
Jung Min LEE, Jae Seung KANG, Hee Ju SOHN, Yoonhyeong BYUN, Yoo Jin CHOI, Youngmin HAN, Eun Joo KIM, Hongbeom KIM, Wooil KWON, Jin-Young JANG*
Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Korea
Introduction : Safety and feasibility of laparoscopic distal pancreatectomy (LDP) in regards to the pancreatic adenocarcinoma (PDAC) were not well-known. The present study aimed to compare the short-term and long-term outcomes of LDP with those of open distal pancreatectomy (ODP).
Methods : This was a retrospective study with prospectively collected medical data. Between 2009 and 2017, patients who underwent distal pancreatectomy and pathologically confirmed as PDAC were enrolled. Clinical and pathologic variables were investigated. To reduce selection bias, 1:1 propensity score matching (PSM) was performed with T and N stage of 8th American Joint Committee on Cancer staging system. Survival outcomes and cumulative recurrence rates were calculated with Kaplan-Meier method.
Results : Total 210 patients were enrolled. LDPs and ODPs were performed in 35 patients (16.7%) and 175 patients (83.3%), respectively. After 1:1 PSM, age, sex, underlying diseases were comparable between two groups. In terms of short-term outcomes, operation time (128 vs. 164 minute, P=0.001) and postoperative hospital stay (11.1 vs. 16.5 days, P=0.011) were significantly different between two groups. Tumor size (3.2 vs. 3.1 cm, P=0.889), number of harvested lymph nodes (12.6 vs. 14.4, P=0.365), and R0 resection rates (91.4 vs. 80.0%, P=0.172) were comparable. 5-year overall survival rates (26.4 vs. 24.6%, P=0.742) and cumulative recurrence rates (56.3 vs. 61.4%, P=0.582) were comparable between two groups.
Conclusions : LDP has similar or better perioperative outcomes (operation time, postoperative hospital stay) and shows similar survival outcomes, and recurrence patterns in PDAC patients, compared with ODP. LDP is a safe and feasible procedure in PDAC patients.
Methods : This was a retrospective study with prospectively collected medical data. Between 2009 and 2017, patients who underwent distal pancreatectomy and pathologically confirmed as PDAC were enrolled. Clinical and pathologic variables were investigated. To reduce selection bias, 1:1 propensity score matching (PSM) was performed with T and N stage of 8th American Joint Committee on Cancer staging system. Survival outcomes and cumulative recurrence rates were calculated with Kaplan-Meier method.
Results : Total 210 patients were enrolled. LDPs and ODPs were performed in 35 patients (16.7%) and 175 patients (83.3%), respectively. After 1:1 PSM, age, sex, underlying diseases were comparable between two groups. In terms of short-term outcomes, operation time (128 vs. 164 minute, P=0.001) and postoperative hospital stay (11.1 vs. 16.5 days, P=0.011) were significantly different between two groups. Tumor size (3.2 vs. 3.1 cm, P=0.889), number of harvested lymph nodes (12.6 vs. 14.4, P=0.365), and R0 resection rates (91.4 vs. 80.0%, P=0.172) were comparable. 5-year overall survival rates (26.4 vs. 24.6%, P=0.742) and cumulative recurrence rates (56.3 vs. 61.4%, P=0.582) were comparable between two groups.
Conclusions : LDP has similar or better perioperative outcomes (operation time, postoperative hospital stay) and shows similar survival outcomes, and recurrence patterns in PDAC patients, compared with ODP. LDP is a safe and feasible procedure in PDAC patients.
SESSION
E-poster
E-Session 7/27 ~ 7/29 ALL DAY