Detailed Abstract
[E-poster]
[EP120] Clinical usefulness of Circulating tumor cells (CTCs) in pancreatic ductal adenocarcinoma
Yejong PARK1, Hye Ryeong JUN2, Dae Wook HWANG1, Jae Hoon LEE1, Ki Byung SONG1, Woohyung LEE1, Jaewoo KWON1, Eunsung JUN1, 3, Song Cheol KIM*1, 2
1Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, Korea
2Biomedical Engineering Research Center, Asan Medical Center, Korea
3Department of Convergence Medicine, Asan Medical Center, Korea
Introduction : The study was to analyze clinical usefulness according to the detection of Circulating tumor cells (CTCs) in patients who underwent curative resection for pancreatic ductal adenocarcinoma (PDAC).
Methods : From 2017 to 2018, peripheral blood mononuclear cell layer was obtained from whole blood from forty patients who pre-diagnosed to PDAC. The CTC was isolated using the CD-PRIMETM platform and detected by immune-staining (CK, CD45, EpCAM). The medical records were reviewed for correlation with recurrence patterns and prognosis after surgical resection
Results : Of the 40 patients, 36 patients were finally diagnosed with PDAC by histologic examination and 12 patients showed CTC positive (33.3%). The recurrence within 6 months and R0 resection were a poor prognostic factor for overall survival. Of the 12 patients who recurred within 6 months, the CTC-positive group showed more recurrence (p=0.329). In particular, recurrence of distant metastasis and peritoneal dissemination were significantly frequent in the CTCs-positive (P = 0.002). In the multivariable analysis, the CTCs-positive was found to be an independent risk factor ( p = 0.020) for metastatic recurrence incidence along with vein resection.
Conclusions : CTCs is associated with early recurrence of distant metastasis and peritoneal dissemination along with vein resection. The patients with CTC at tumor diagnosis require more active monitoring and new treatment strategies before and after surgery, which will help to reduce the risk of early recurrence and improve survival.
Methods : From 2017 to 2018, peripheral blood mononuclear cell layer was obtained from whole blood from forty patients who pre-diagnosed to PDAC. The CTC was isolated using the CD-PRIMETM platform and detected by immune-staining (CK, CD45, EpCAM). The medical records were reviewed for correlation with recurrence patterns and prognosis after surgical resection
Results : Of the 40 patients, 36 patients were finally diagnosed with PDAC by histologic examination and 12 patients showed CTC positive (33.3%). The recurrence within 6 months and R0 resection were a poor prognostic factor for overall survival. Of the 12 patients who recurred within 6 months, the CTC-positive group showed more recurrence (p=0.329). In particular, recurrence of distant metastasis and peritoneal dissemination were significantly frequent in the CTCs-positive (P = 0.002). In the multivariable analysis, the CTCs-positive was found to be an independent risk factor ( p = 0.020) for metastatic recurrence incidence along with vein resection.
Conclusions : CTCs is associated with early recurrence of distant metastasis and peritoneal dissemination along with vein resection. The patients with CTC at tumor diagnosis require more active monitoring and new treatment strategies before and after surgery, which will help to reduce the risk of early recurrence and improve survival.
SESSION
E-poster
E-Session 7/27 ~ 7/29 ALL DAY