Detailed Abstract
[E-poster]
[EP122] The proposal of therapeutic drugs through drug response of tissue culture in pancreatic cancer
Eunsung JUN1, 2, Yejong PARK1, Woohyung LEE1, Jaewoo KWON1, Ki Byung SONG1, Dae Wook HWANG1, Jae Hoon LEE1, Song Cheol KIM*1
1Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, Korea
2Department of Convergence Medicine, Asan Medical Center, Korea
Introduction : Because the prognosis of pancreatic cancer is extremely poor, most patients received chemotherapy with surgery. However, considering the tumor heterogeneity of each patient, it is difficult to select the most effective chemotherapeutic agent. The aim of this study was to propose a chemotherapy regimen that is most appropriate for patients after surgical resection.
Methods : We utilized an in vitro system that can directly examine the therapeutic effect of cancer tissues on drug regimens. From 2015 to 2017, tissue culture was performed using tumor pieces of patients who underwent surgery. The drug response was confirmed by constructing various regimens with clinically used drugs (single; 10 types, double; 6 types, triple; 3 types).
Results : First, double or triple combination regimen showed higher drug efficacy and less patient variation than single drug. In particular, 5-FU/Bel/Oxa and TS-1/Oxa/Irino regimens were proposed as the most effective drugs. Second, we could select drugs with different efficacy according to the degree of tumor progression of primary cancer. Third, when constructing regimens containing 5FU or gemcitabine, more effective drug regimens could be selected.
Conclusions : This study was the first study to verify the usefulness of the histoculture drug response in pancreatic cancer, we hope the prognosis of patients with pancreatic cancer will be improved by applying the best chemotherapeutic agent to patients.
Methods : We utilized an in vitro system that can directly examine the therapeutic effect of cancer tissues on drug regimens. From 2015 to 2017, tissue culture was performed using tumor pieces of patients who underwent surgery. The drug response was confirmed by constructing various regimens with clinically used drugs (single; 10 types, double; 6 types, triple; 3 types).
Results : First, double or triple combination regimen showed higher drug efficacy and less patient variation than single drug. In particular, 5-FU/Bel/Oxa and TS-1/Oxa/Irino regimens were proposed as the most effective drugs. Second, we could select drugs with different efficacy according to the degree of tumor progression of primary cancer. Third, when constructing regimens containing 5FU or gemcitabine, more effective drug regimens could be selected.
Conclusions : This study was the first study to verify the usefulness of the histoculture drug response in pancreatic cancer, we hope the prognosis of patients with pancreatic cancer will be improved by applying the best chemotherapeutic agent to patients.
SESSION
E-poster
E-Session 7/27 ~ 7/29 ALL DAY