Detailed Abstract
[Liver Poster Presentation 2]
[LV PP 2-1] The effect of selenium on the immunity of patients after partial liver resection – A pilot study.
In Sik SHIN1, Deok Gie KIM1, Sung whan CHA*1, Seong Hee KANG2, Sung Hoon KIM1, Moon Young KIM2, Soon Koo BAIK2
1Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Korea
2Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Korea
Introduction : The liver is enriched in several innate and adaptive immune cells. The immunity of liver is very important. The selenium is known as the trace element that is associated with inflammatory, immune cell function and immune-related disease and cancer. We investigate the effect of selenium on the immunity of patients after liver resection.
Methods : We collected prospectively the count of T cell and B cell at preoperative (POD) day before and POD one month after liver resection. Thirty-one patients were enrolled from Oct. 2018 to Aug. 2019. We categorized the patients into two group based on taking selenium or not. We investigated the immune cell count and the difference of immune cell counts was compared between the day before surgery and the month after surgery.
Results : Eight patients (Group 1) did not take selenium and 23 patients (group 2) took. The frequency and count of preoperative T and B cell and POD T cell were similar between both groups. However, the frequency and count of B cell were higher in group 2 [136 (61.6-339.5), 9.3 (4-22.6)] than in group 1 [74 (6-264), 6.4 (0.6-12.3)]. Another inflammatory marker, neutrophil to lymphocyte ratio was rapidly decreased in group 2 (preop 2.31, POD 5days 8.38, POD 1month 2.28) than group 1 (2.40,9.89,10.11).
Conclusions : B cell and the change of inflammatory marker was reported as a good predictive marker for liver regeneration and survival after liver resection. Although we need large-scale and long-term results, the selenium may increase survival by inducing improvement of immune system.
Methods : We collected prospectively the count of T cell and B cell at preoperative (POD) day before and POD one month after liver resection. Thirty-one patients were enrolled from Oct. 2018 to Aug. 2019. We categorized the patients into two group based on taking selenium or not. We investigated the immune cell count and the difference of immune cell counts was compared between the day before surgery and the month after surgery.
Results : Eight patients (Group 1) did not take selenium and 23 patients (group 2) took. The frequency and count of preoperative T and B cell and POD T cell were similar between both groups. However, the frequency and count of B cell were higher in group 2 [136 (61.6-339.5), 9.3 (4-22.6)] than in group 1 [74 (6-264), 6.4 (0.6-12.3)]. Another inflammatory marker, neutrophil to lymphocyte ratio was rapidly decreased in group 2 (preop 2.31, POD 5days 8.38, POD 1month 2.28) than group 1 (2.40,9.89,10.11).
Conclusions : B cell and the change of inflammatory marker was reported as a good predictive marker for liver regeneration and survival after liver resection. Although we need large-scale and long-term results, the selenium may increase survival by inducing improvement of immune system.
SESSION
Liver Poster Presentation 2
E-Session 7/27 ~ 7/29 ALL DAY