Detailed Abstract
[BP Best Oral Presentation]
[BP BEST OP 4] Effects of Pancreatectomy on Nutritional State, Pancreatic Function and Quality of Life for 5 Years Follow-up
Yong Chan SHIN1, Jin-Young JANG*2
1Department of Surgery, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
2Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Introduction : The purpose of this study was to analyze long-term changes in nutritional status, pancreatic function and quality of life (QoL) for 5 years follow-up after pancreatectomy.
Methods : Consecutive patients undergoing pancreaticoduodenectomy (PD) or distal pancreatectomy (DP) between 2007 and 2013 were included. Relative bodyweight (RBW), triceps skinfold thickness (TSFT), body mass index (BMI), serum protein, albumin, transferrin, fasting blood glucose, postprandial 2-h glucose (PP2), glycosylated hemoglobin A1c, insulin, c-peptide and stool elastase measurements, and European Organization for Research and Treatment of Cancer QLQ-C30/QLQ-PAN26 questionnaires were collected serially for 5 years.
Results : At the beginning of the study, a total of 217 patients were enrolled, but only 79 patients completed 5 years follow-up. RBW, BMI and TSFT continued to decrease after surgery and increased since the 6-month follow-up. Transferrin, albumin and protein levels had recovered to the preoperative level by the 3-month follow-up. Multivariate analysis revealed that BMI higher than 25, distal pancreatectomy and adjuvant therapy had a significant impact on the endocrine pancreatic insufficiency. Although steatorrhoea and diarrhoea had mainly resolved by 12 months, stool elastase level decreased after pancreaticoduodenectomy and showed no recovery. The mean scores of all the QoL questionnaires improved above the preoperative value at 12 months postoperatively, except for the diarrhea scale that did not recover throughout the study.
Conclusions : Patients undergoing pancreatectomy can returned to their daily lives at postoperative 12-months. However, those with risk factors associated with pancreatic function and QoL need more careful follow-up and supportive management.
Methods : Consecutive patients undergoing pancreaticoduodenectomy (PD) or distal pancreatectomy (DP) between 2007 and 2013 were included. Relative bodyweight (RBW), triceps skinfold thickness (TSFT), body mass index (BMI), serum protein, albumin, transferrin, fasting blood glucose, postprandial 2-h glucose (PP2), glycosylated hemoglobin A1c, insulin, c-peptide and stool elastase measurements, and European Organization for Research and Treatment of Cancer QLQ-C30/QLQ-PAN26 questionnaires were collected serially for 5 years.
Results : At the beginning of the study, a total of 217 patients were enrolled, but only 79 patients completed 5 years follow-up. RBW, BMI and TSFT continued to decrease after surgery and increased since the 6-month follow-up. Transferrin, albumin and protein levels had recovered to the preoperative level by the 3-month follow-up. Multivariate analysis revealed that BMI higher than 25, distal pancreatectomy and adjuvant therapy had a significant impact on the endocrine pancreatic insufficiency. Although steatorrhoea and diarrhoea had mainly resolved by 12 months, stool elastase level decreased after pancreaticoduodenectomy and showed no recovery. The mean scores of all the QoL questionnaires improved above the preoperative value at 12 months postoperatively, except for the diarrhea scale that did not recover throughout the study.
Conclusions : Patients undergoing pancreatectomy can returned to their daily lives at postoperative 12-months. However, those with risk factors associated with pancreatic function and QoL need more careful follow-up and supportive management.
SESSION
BP Best Oral Presentation
Room B 7/28/2020 2:10 PM - 2:20 PM