Detailed Abstract
[E-poster]
[EP041] Comparable Outcomes in Living Donor and Deceased Donor Liver Transplantation for Patients with High Model for End-stage Liver Disease Scores
Boram LEE, YoungRok CHOI*, Jai Young CHO, Yoo-Seok YOON, Ho-Seong HAN
Department of Surgery, Seoul National University Bundang Hospital, Korea
Introduction : The purpose of this study is to evaluate the outcomes between living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) for patients with MELD (≥25).
Methods : Prospectively collected EMR data of 132 consecutive recipients who underwent LT from 2009 to 2018 were reviewed. Patients with high MELD score (≥25) were divided into two groups LDLT and DDLT group for comparing of short- and long-term outcomes.
Results : Among 64 eligible patients, 24 patients underwent LDLT and 40 patients underwent DDLT.. There were no significantly differences between the two groups with regards to demographics including age, gender except etiology of liver disease (LDLT group, hepatitis B virus : 33.3%, Alcoholics : 20.8%, Fulminant hepatitis : 45.8% ; DDLT group, hepatitis B virus : 57.5%, Alcoholics : 27.5%, Autoimmune hepatitis : 7.5%, P=0.002). Preoperative medication status of those patients such as intensive care unit admission, applying mechanical ventilation or hemodialysis and presence of hepatorenal syndrome were not different significantly between two groups. The LDLT group had lower graft weight to recipient weight ratio (1.14±0.29 vs 2.14±0.61, P=0.004), shorter cold ischemic time (min) (67.6±31.1 vs 310.0±212.1, P=0.002). Two groups were comparable in terms of hospital days, postoperative complications, and 30-day mortality. The patient survival at one year (96.0% vs 92.0%), three year (96.0% vs 89.0%) and five years (85.0% vs 80.0%) was comparable between LDLT and DDLT groups (P=0.395).
Conclusions : LDLT shows comparable outcomes in the short and long-term survival compared to DDLT for patients with high MELD score.
Methods : Prospectively collected EMR data of 132 consecutive recipients who underwent LT from 2009 to 2018 were reviewed. Patients with high MELD score (≥25) were divided into two groups LDLT and DDLT group for comparing of short- and long-term outcomes.
Results : Among 64 eligible patients, 24 patients underwent LDLT and 40 patients underwent DDLT.. There were no significantly differences between the two groups with regards to demographics including age, gender except etiology of liver disease (LDLT group, hepatitis B virus : 33.3%, Alcoholics : 20.8%, Fulminant hepatitis : 45.8% ; DDLT group, hepatitis B virus : 57.5%, Alcoholics : 27.5%, Autoimmune hepatitis : 7.5%, P=0.002). Preoperative medication status of those patients such as intensive care unit admission, applying mechanical ventilation or hemodialysis and presence of hepatorenal syndrome were not different significantly between two groups. The LDLT group had lower graft weight to recipient weight ratio (1.14±0.29 vs 2.14±0.61, P=0.004), shorter cold ischemic time (min) (67.6±31.1 vs 310.0±212.1, P=0.002). Two groups were comparable in terms of hospital days, postoperative complications, and 30-day mortality. The patient survival at one year (96.0% vs 92.0%), three year (96.0% vs 89.0%) and five years (85.0% vs 80.0%) was comparable between LDLT and DDLT groups (P=0.395).
Conclusions : LDLT shows comparable outcomes in the short and long-term survival compared to DDLT for patients with high MELD score.
SESSION
E-poster
E-Session 7/27 ~ 7/29 ALL DAY