Detailed Abstract
[Liver Oral Presentation 3]
[LV OP 3-6] surgical outcome after microscopic incomplete resection (R1) of colorectal liver metastases in the era of agressive surgical approach
Essam ALHOTHAIFI2, Gi Hong CHOI*1, Dai Hoon HAN1, Kyung Sik KIM1, Jin Sub CHOI1
1Division of HBP surgery , Department of Surgery, Yonsei University College of Medicine, Korea
2Division of HBP surgery , Department of Surgery, King Saud Medical City, Saudi Arabia
Introduction : A>= 1-mm margin is standard for resection of colorectal liver metastases(CLRM) . However , microscopic incomplete resection (R1) is not rate because agressive surgical resection has been attempted in multiple and bilobar CLM. in this study , we analyzed surgical outcomes after R1 resection of CRLM.
Methods : From 2005 to 2018, 371 consecutive patients undergoing liver resection for CRLM were included. R1 resection was defined to have Zero tumor free margin at the pathologic report. All patients were divided into R0 (tumor free margin more than 0 mm) and R1 group. Recurrence pattern and disease-free survival were analyzed between the two groups.
Results : A total of 371 patients included in the study. Among them, R1 resection was found in 42 (11.3%) patients. The median age at diagnosis was 59 years (range, 22 to 86). There were 246 (33.7%) men and 125 women (66.3%). The incidence of intrahepatic recurrence was not significantly different between R0 and R1 resection. Similarly, there was no significant difference in term of surgical margin recurrences between patients with R0 and R1 resections (42% [35/84] vs 35% [6/17], respectively, P = 0.788). When comparing R0 and R1 resection, the 1-, 3-, and 5-year disease-free survival rates was not statistically significant.
Conclusions : R1 resection showed similar marginal recurrence rate and comparable disease-free survival compared to R0 resection. R1 resection should be part of the modern multidisciplinary, aggressive approach to CRLM.
Methods : From 2005 to 2018, 371 consecutive patients undergoing liver resection for CRLM were included. R1 resection was defined to have Zero tumor free margin at the pathologic report. All patients were divided into R0 (tumor free margin more than 0 mm) and R1 group. Recurrence pattern and disease-free survival were analyzed between the two groups.
Results : A total of 371 patients included in the study. Among them, R1 resection was found in 42 (11.3%) patients. The median age at diagnosis was 59 years (range, 22 to 86). There were 246 (33.7%) men and 125 women (66.3%). The incidence of intrahepatic recurrence was not significantly different between R0 and R1 resection. Similarly, there was no significant difference in term of surgical margin recurrences between patients with R0 and R1 resections (42% [35/84] vs 35% [6/17], respectively, P = 0.788). When comparing R0 and R1 resection, the 1-, 3-, and 5-year disease-free survival rates was not statistically significant.
Conclusions : R1 resection showed similar marginal recurrence rate and comparable disease-free survival compared to R0 resection. R1 resection should be part of the modern multidisciplinary, aggressive approach to CRLM.
SESSION
Liver Oral Presentation 3
Room A 7/28/2020 8:45 AM - 8:52 AM