Detailed Abstract
[E-poster]
[EP072] Survival outcomes and recurrence patterns of intracholecystic papillary neoplasm of the gallbladder compared with conventional gallbladder adenocarcinoma
Jae Seung KANG1, Kyung Bun LEE2, Yoo Jin CHOI1, Yoonhyeong BYUN1, Youngmin HAN1, Hongbeom KIM1, Wooil KWON1, Jin-Young JANG*1
1Surgery and Cancer Research Institute, Seoul National University College of Medicine, Korea
2Pathology, Seoul National University College of Medicine, Korea
Introduction : Intracholecystic papillary neoplasm (ICPN) of the gallbladder (GB) is a tumoral intraepithelial neoplasm that grows exophytically into the GB lumen. Few studies were found to investigate the prognosis of ICPN after curative-intent surgery. This study was to investigate the demographic, pathologic findings, and prognosis and recurrence patterns of ICPN, and to compare them with conventional gallbladder adenocarcinoma (GBC).
Methods : Between 2000 and 2018, patients who underwent surgical resection due to suspicious GB cancer were included. ICPN was defined if a size was ≥1.0cm, a papillary or polypoid mass grew exophytically into the GB lumen. Demographic, pathologic findings, prognosis and recurrence patterns were evaluated and compared with those of conventional GBC.
Results : Of total 607 patients, 241 patients (39.7%) were pathologically diagnosed of ICPN. ICPNs were surgically removed at earlier stage compared with conventional GBC that half of ICPNs were T1 or less. the rate of regional lymph node metastasis and distant metastasis was lower, respectively (23.8 vs. 50.4%, P<0.001; 6.2 vs. 19.1%, P<0.001). Totally, 5-year overall survival (OS) rates was higher in ICPN (73.1 vs 43.4%, P<0.001). However, 5-year OS rates were comparable in each T stage following stage-matched analysis. Overall recurrence rates were lower in ICPN (14.6 vs. 38.1%, P<0.001), but local recurrence rates and site of systemic recurrence was comparable between two lesions except for lower peritoneal seeding of ICPN.
Conclusions : ICPN showed comparable survival outcome compared with staged-matched conventional GBC, and similar recurrence patterns. The treatment strategy has to follow the same protocols of conventional GBC.
Methods : Between 2000 and 2018, patients who underwent surgical resection due to suspicious GB cancer were included. ICPN was defined if a size was ≥1.0cm, a papillary or polypoid mass grew exophytically into the GB lumen. Demographic, pathologic findings, prognosis and recurrence patterns were evaluated and compared with those of conventional GBC.
Results : Of total 607 patients, 241 patients (39.7%) were pathologically diagnosed of ICPN. ICPNs were surgically removed at earlier stage compared with conventional GBC that half of ICPNs were T1 or less. the rate of regional lymph node metastasis and distant metastasis was lower, respectively (23.8 vs. 50.4%, P<0.001; 6.2 vs. 19.1%, P<0.001). Totally, 5-year overall survival (OS) rates was higher in ICPN (73.1 vs 43.4%, P<0.001). However, 5-year OS rates were comparable in each T stage following stage-matched analysis. Overall recurrence rates were lower in ICPN (14.6 vs. 38.1%, P<0.001), but local recurrence rates and site of systemic recurrence was comparable between two lesions except for lower peritoneal seeding of ICPN.
Conclusions : ICPN showed comparable survival outcome compared with staged-matched conventional GBC, and similar recurrence patterns. The treatment strategy has to follow the same protocols of conventional GBC.
SESSION
E-poster
E-Session 7/27 ~ 7/29 ALL DAY